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US 6,441,194 B1Granted
Synthesis of 4-substituted pyrrole-2-carbaldehyde compounds
AssigneeEmory University
InventorsLanny S. Liebeskind, Wansheng Liu
Life of this patent
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Abstract
The invention relates to an a process for making a 4-substituted pyrrole-2-carbaldehyde compound comprising reacting: a. a pyrrole-2-carbaldehyde compound; and b. an alkylating agent; c. in the presence of at least one catalyst; to form a 4-alkyl substituted pyrrole-2-carbaldehyde compound.
Claims22
A process for making a 4-alkyl substituted pyrrole-2-carbaldehyde compound comprising reacting:
- a. a pyrrole-2-carbaldehyde compound prepared by reacting a pyrrole compound with a Vilsmeir reagent;
- and
- b. an alkylating agent having at least four carbon atoms;
- in the presence of at least one catalyst;
- to form a 4-alkyl substituted pyrrole-2-carbaldehyde compound.
2 more elements
A process for making 4-t-butyl-pyrrole-2-carbaldehyde compound comprising:
- a. dispersing pyrrole-2-carbaldehyde prepared by reacting a pyrrole compound with a Vilsmeir reagent and from about 1.0 to about 1.5 molar equivalents of AlCl3 in a solvent:
- b. adding from about 0.8 to about 1.3 molar equivalents of a t-butyl-halide compound to the dispersion, and
- c. reacting the dispersion to form 4-t-butylpyrrole-2-carbaldehyde.
Dependencies are inferred from the claim text.