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US 6,441,184 B1Granted
Fused heteroaromatic glucokinase activators
AssigneeHoffmann-La Roche Inc.
InventorsWendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
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Abstract
Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.
Claims58
A compound selected from the group consisting of an amide of formula:
- and a pharmaceutically acceptable salt thereof;
- wherein
- R1 is an alkyl having from 1 to 3 carbon atoms;
- R2 is hydrogen, halo, nitro, cyano, or perfluoro-methyl;
- R3 is a cycloalkyl having from 4 to 7 carbon atoms or 2-propyl;
- Z is —CH2—CH2—CH2—CH2— or —CH═CR4—CH═CH—,
- wherein R4 is hydrogen, halo, or an alkyl sulfone having from 1 to 3 carbon atoms;
- W is O, S or NH;
- and
- * denotes an asymmetric carbon.
7 more elements
Dependencies are inferred from the claim text.