Resolution of ritalinic acid salt
AssigneeMedeva Europe Limited
InventorsHooshang Shahriari Zavareh, Gerard Andrew Potter
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Abstract
A process for preparing an enantiomerically-enriched form of threo-ritalinic acid, which comprises resolving a mixture of enantiomers of a salt of the acid, said salt being formed with an achiral acid or base, using a chiral resolving agent. The resolved salt can be esterified, to give the therapeutic agent d-threo-methylphenidate.
Claims10
A process for preparing an enantiomerically-enriched form of a double salt of threo-ritalinic acid having two counterions, wherein said double salt has a 1:2 ratio of acid:counterion, comprising forming a threo-ritalinic acid addition salt using an achiral acid and then resolving enantiomers of said achiral acid addition salt with a single chiral resolving base.
A double salt of threo-ritalinic acid, predominantly as a single enantiomer thereof, comprising one anionic counterion and one cationic counterion, wherein said anionic counterion is achiral and the other is derived from a single enantiomer chiral resolving agent.
Dependencies are inferred from the claim text.