Tertiary amines

A compound of the formula:

• wherein
• A1 is C1-C20 alkyl,
• A2 is OH, C3-C6 cycloalkyl, C3-C6 cycloalkyl-C1-C20-alkyl, unsubstituted C1-C20 alkyl, unsubstituted C3-C20 alkenyl, C1-C20 alkyl substituted by R1, CONH2 or CN, or C3-C20 alkenyl substituted by R1, CONH2 or CN, and
• A3 and A4 are each independently hydrogen or C1-C20 alkyl;
• or
• A1 is C3-C20 alkenyl,
• A2 is C3-C6 cycloalkyl, C3-C6 cycloalkyl-C1-C20-alkyl, unsubstituted C1-C20 alkyl, unsubstituted C3-C20 alkenyl, C1-C20 alkyl substituted by R1, CONH2 or CN, or C3-C20 alkenyl substituted by R1, CONH2 or CN, and when A1 is C1-C20 alkyl, and
• A3 and A4 are each independently hydrogen or C1-C20 alkyl;
• or
• A1 and A2 together form a C2-C8 alkylene, C4-C8 alkenylene, C6-C8 alkadienylene, R1 substituted C2-C8 alkylene, R1 substituted C4-C8 alkenylene, or R1 substituted C6-C8 alkadienylene group A1-A2, or
• A1 and A2 together form a C2-C8 alkylene, C4-C8 alkenylene, C6-C8 alkadienylene, R1 substituted C2-C8 alkylene, R1 substituted C4-C8 alkenylene, or R1 substituted C6-C8 alkadienylene group A1-A2, wherein one or two C atoms are replaced by one or two groups selected from the group consisting of N atoms and N(C1-C20 alkyl), or
• A1 and A3 together form a C2-C8 alkylene, C4-C8 alkenylene, C6-C8 alkadienylene, R1 substituted C2-C8 alkylene, R1 substituted C4-C8 alkenylene, or R1 substituted C6-C8 alkadienylene group A1-A3, or
• A1 and A3 together form a C2-C8 alkylene, C4-C8 alkenylene, C6-C8 alkadienylene, R1 substituted C2-C8 alkylene, R1 substituted C4-C8 alkenylene, or R1 substituted C6-C8 alkadienylene group A1-A3, wherein one or two C atoms are replaced by one or two groups selected from the group consisting of N atoms and N(C1-C20 alkyl);
• R1 is OH, oxo, C1-C20 alkyl(O), C1-C20 alkyl(S) or di(C1-C20 alkyl)amino bonded to a saturated C atom of A2, A1-A2 or A1-A3, provided that a C atom substituted by R1 or an unsaturated C atom present in A1, A2, A1-A2 or A1-A3 must be bonded in a position other than the α-position to N(A1A2);
• p=1 and L is phenylene, C4-C11 alkylene which has at least 4 C atoms between the two free valencies or C3-C11 alkenylene which has at least 3 C atoms between the two free valencies, and which is bonded to M directly or via O, NH or N(C1-C20 alkyl) or N(C1-C20 alkanoyl), or L is C3-C6 cycloalkylene-C1-C20-alkylene, or
• p=0 and L is C6-C11-alkenylene or C6-C11-alkadienylene, bonded to T;
• M is thienylene, pyridylene, 1,4-phenylene, 1,4-phenylene substituted by at least one substituent selected from the group consisting of C1-C20 alkyl, halogen, N(R2,R21), CONH2, CN, NO2, CF3, OH, C1-C20 alkyl(O), C1-C20 alkyl(S), 1,2,4-triazol-1-yl and tetrazol-1-yl, or a group of the formula:
• q is 1 or 0;
• R2 and R21 are independently H, C1-C20 alkyl, C2-C20 alkenyl, C1-C20 alkanoyl or SO2—(C1-C20 alkyl);
• T is CO, CH(R3), C(R4,R5) or C═NOR6 and, when M is a group M1 and q=0, T can also be SO2;
• R3 is OH, F, C1-C20 alkoxy or C1-C20 alkanoyloxy;
• R4 is OH and R5 is C1-C20 alkyl, C2-C20 alkenyl, C2-C20 alkinyl, cycloalkyl or CF3, or
• R4 and R5 together are the group CH2, CH2O or CH2CH2;
• R6 is H, C1-C20 alkyl or C2-C20 alkenyl;
• Q is C3-C6 cycloalkyl, C(R7,R8), phenyl substituted by at least one substituent selected from the group consisting of C1-C20 alkyl, halogen, N(R9,R10), CONH2, CN, NO2, CF3, 1,2,4-triazol-1-yl and tetrazol-1-yl, or a straight-chain C6-C13 alkyl, C6-C13 alkenyl, C6-C13 alkadienyl or C6-C13 alkatrienyl group Q′ with 0 to 3 methyl substituents, and a group Q′ can be substituted by at least one substituent selected from the group consisting of OH and N(R9,R10),
• R7 and R8 are C5-C11-alkyl, C5-C11-alkenyl or C5-C11-alkadienyl, and
• R9 and R10 are H, C1-C20 alkyl, C2-C20 alkenyl or C1-C20 alkanoyl, provided that
• (a) A2 must not be C1-C20 alkyl or C3-C20 alkenyl, or A1 and A2 together must not be C2-C8 alkylene in a compound of formula I in which T is a group CO or CHOH, L is phenylene or an C4-C11 alkylene or C3-C11 alkenylene group bonded to M directly or via 0 or N(C1-C20 alkyl), M is 1,4-phenylene or 1,4-phenylene monosubstituted by C1-C20 alkyl, C1-C20 alkyl(O), halogen, CN, NO2 or CF3, and Q is substituted phenyl, C6-C13 alkenyl, C6-C13 alkyl or C6-C13 alkyl substituted by OH,
• (b) M must not be pyridylene in a compound of formula I in which A1 and A2 together are C2-C8 alkylene or C2-C8 alkylene substituted by R1, A2 is C1-C20 hydroxyalkyl or A1 and A2 are each C1-C20 alkyl, and
• (c) in a compound of formula I in which T is a group C(OH, R51), wherein R51 is C1-C20 alkyl, C2-C20 alkenyl, C2-C20 alkynyl or C3-C6 cycloalkyl, M is 1,4-phenylene or substituted 1,4-phenylene and L is an alkylene group bonded to M via a O atom, the alkylene must be a C5-C11 alkylene containing at least 5 C atoms between the 2 free valencies,
• or a pharmaceutically usable acid addition salt thereof.