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AssigneeTanox, Inc.
InventorsMichael C. Kiefer, Paul A. Fitzpatrick, Helen L. Gibson, Philip J. Barr
Estimating the term…
The present invention provides polynucleotide sequences (bbp) encoding a Bak Binding Protein (BBP) and fragments thereof that bind to Bak. The invention also provides a BBP which binds to Bak. The invention also provides recombinant host cells containing polynucleotides encoding BBP. The invention further provides antibodies that specifically bind to BBP. The invention further provides methods for detecting agents such as drugs that alter the binding of a BBP with a Bak protein. The invention neither provides methods for detecting the presence of bbp or BBP in a biological sample, and further provides methods for modulating the levels of BBP in a cell. This invention additionally encompasses novel peptides, designated the “BBP Binding Domains” and the respective nucleotides, designated “bbpbd-1” and “bbpbd-2” which arc involved in the interaction between Bak and BBP.
An isolated polypeptide comprising SEQ ID NO:7 or a fragment thereof, where ad fragment comprises a linear sequence of at least six into acid residues of SEQ ID NO:7, and wherein said fragment binds to a Bak protein.
A fusion polypeptide comprising the polypeptide of SEQ ID NO:7 or a fragment thereof comprising a linear sequence of at least six amino acid residues of SEQ ID NO:7, wherein said fragment binds to a Bak protein.
A method for screening potential therapeutic agents that increase the binding between Bak and Bak binding protein (BBP) comprising the steps of:
An isolated and purified polypeptide that is between 6 and 50 amino acid residues in length, said polypeptide comprising a Bak binding protein (BBP) Binding Domain or a at least 6 linear amino acid fragment thereof, wherein said fragment binds to a Bak binding protein (BBP), and wherein said BBP Binding Domain is selected from the group consisting of:
A method for screening potential therapeutic agents that decrease the binding between Bak and Bak binding protein (BBP) comprising the steps of:
A fusion polypeptide comprising a Bak binding protein (BBP) Binding Domain, wherein said BBP Binding Domain binds to a Bak binding protein (BBP), and wherein said BBP Binding Domain is selected from the group consisting of:
An isolated polypeptide consisting of amino acid residues 138-164 of SEQ ID NO:2.
An isolated polypeptide consisting of amino acid residues 103-126 of SEQ ID NO:2.
Dependencies are inferred from the claim text.