Contryphan peptides
AssigneeUniversity of Utah Research Foundation
InventorsElsie C. Jimenez, Baldomero M. Olivera, William R. Gray, Lourdes Cruz
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Abstract
The present invention is directed to contryphan peptides having 6-12 amino acids, preferably including one or more D-tryptophan residues. More specifically, the present invention is directed to contryphan peptides having the general formula Xaa1-Cys-Xaa2-Xaa3-Glu-Pro-Trp-Cys (SEQ ID NO:1), wherein Xaa1 is Gly or des-Xaa1, Xaa2 is Pro or 4-trans-hydroxyproline and Xaa3 is D-Trp or L-Trp, preferably D-Trp. The present invention is further directed to the peptides contryphan R and des-Gly1 contryphan R. In contryphan R, Xaa1 is Gly and Xaa3 is D-Trp. These contryphans are useful as anticonvulsant or neuroprotective agents.
Claims8
A substantially pure contryphan peptide of the generic formula:
- Xaa1-Cys-Xaa2-Xaa3-Glu-Pro-Trp-Cys (SEQ ID NO:1),
- wherein
- Xaa1 is Gly or des-Xaa1,
- Xaa2 is Pro or 4-trans-hydroxyproline and
- Xaa3 is D-Trp or L-Trp.
Dependencies are inferred from the claim text.