Back to results
US 6,441,047 B2Granted
Combination therapy for treating glaucoma
AssigneeAlcon Manufacturing, Ltd.
InventorLouis DeSantis, Jr.
Life of this patent
Estimating the term…
Abstract
Methods for treating persons with glaucoma or ocular hypertension with glutamate antagonists and IOP-lowering compounds are disclosed.
Claims8
The method for treating a person suffering from glaucoma or ocular hypertension which comprises, administering at least one glutamate antagonist wherein the glutamate antagonist has the structure:
- Y,X=OH, H
- m=0-3
- n, p=1,2
- R1═H, halogen, trifluoromethyl, C1-4 alkyl, OH, C1-4 alkoxy, benzyloxy, C1-16 alkanoyloxy, benzoyloxy or when R2=OH or methoxy in the 4-position and R3=H then R1=hydroxymethyl, carbamoyl, or C1-4 alkoxycarbonyl;
- R2=H, halogen, C1-4 alkyl, OH, C1-4 alkoxyl;
- R3, R4=H, C1-4 alkyl;
- and
- R5=H, halogen, trifluoromethyl, C1-4 alkyl, OH, C1-4 alkoxy, benzyloxy, C1-16 alkanoyloxy, benzoyloxy and all isomers and pharmaceutically acceptable salts and at least one intraocular pressure lowering agent.
5 more elements
A composition comprising a glutamate antagonist with the following structure:
- Y,X=OH, H
- m=0-3
- n, p=1,2
- R1═H, halogen, trifluoromethyl, C1-4 alkyl, OH, C1-4 alkoxy, benzyloxy, C1-16 alkanoyloxy, benzoyloxy or when R2=OH or methoxy in the 4-position and R3=H then R1=hydroxymethyl, carbamoyl, or C1-4 alkoxycarbonyl;
- R2=H, halogen, C1-4 alkyl, OH, C1-4 alkoxyl;
- R3, R4=H, C1-4 alkyl;
- and
- R5=H, halogen, trifluoromethyl, C1-4 alkyl, OH, C1-4 alkoxy, benzyloxy, C1-16 alkanoyloxy, benzoyloxy and all isomers and pharmaceutically acceptable salts and at least one intraocular pressure lowering agent.
5 more elements
Dependencies are inferred from the claim text.