Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use

A composition comprising one or more compounds of formula I

• in which
• R1 is methyl, ethyl, propyl, or butyl;
• R2 is H, OH, NH2, or NH-(C1-C6)-alkyl;
• R3 is a sugar radical, a disugar radical, a trisugar radical, a tetrasugar radical, wherein said radicals are optionally mono- or polysubstituted by a sugar protective group;
• R4is methyl, ethyl, propyl, or butyl;
• R5 is methyl, ethyl, propyl, or butyl;
• Z is —(C═O)n-(C0-C16)-alkyl, —(C═O)n-(C0-C16)-alkyl-N H—, —(C═O)n-(C0-C16)-alkyl-O—, —(C═O)n-(C1-C16)-alkyl-(C═O)m, or a covalent bond;
• n is 0 or 1;
• m is 0 or 1;
• or a pharmaceutically tolerable salt thereof, or a physiologically functional derivative thereof, and which also comprises one or more of simvastain, fluvastatin, pravastatin, cerivastatin, lovastatin and atorvastatin.