Sulphonyloxazolamines as therapeutic active ingredients

A method for treating a disorder of the central nervous system, comprising administering an effective amount of a compound of formula I to a patient in need thereof

• in, which
• R1, R2 each independently of one another are H, A, —(CH2)n—Ar or alkenyl having 2 to 6 atoms,
• R1 and R2 together are also a mononuclear saturated heterocycle having 1 or 2 N, O and/or S atoms,
• Z is H, A, CF3, NO2, Hal, OH, NH2, NHA or NA2,
• A is alkyl having 1 to 6 C atoms,
• Ar is phenyl which is mono- or disubstituted by Z,
• Hal is F, Cl, Br or I,
• n is 1 or 2.

A method for the treatment of psychoses, schizophrenia, manic depression, depression, neurological disorders, memory disorders, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease, bulimia, anorexia nervosa, eating disorders, compulsive acts or premenstrual syndrome, comprising administering an effective amount of a compound of formula I to patient in need thereof

• in, which
• R1, R2 each independently of one another are H, A, —(CH2)n—Ar or alkenyl having 2 to 6 atoms,
• R1 and R2 together are also a mononuclear saturated heterocycle having 1 or 2 N, O and/or S atoms,
• Z is H, A, CF3, NO2, Hal, OH, NH2, NHA or NA2,
• A is alkyl having 1 to 6 C atoms,
• Ar is phenyl which is mono- or disubstituted by Z,
• Hal is F, Cl, Br or I,
• n is 1 or 2.

A pharmaceutical composition, comprising a compound of formula I

• in, which
• R1, R2 each independently of one another are H, A, —(CH2)n—Ar or alkenyl having 2 to 6 atoms,
• R1 and R2 together are also a mononuclear saturated heterocycle having 1 or 2 N, O and/or S atoms,
• Z is H, A, CF3, NO2, Hal, OH, NH2, NHA or NA2,
• A is alkyl having 1 to 6 C atoms,
• Ar is phenyl which is mono- or disubstituted by Z,
• Hal is F, Cl, Br or I,
• n is 1 or 2
• and a pharmaceutically acceptable carrier.

A method for treating a disease mediated by 5-HT6 receptors, comprising administering an effective amount of a compound of formula I to patient in need thereof

• in, which
• R1, R2 each independently of one another are H, A, —(CH2)n—Ar or alkenyl having 2 to 6 atoms,
• R1 and R2 together are also a mononuclear saturated heterocycle having 1 or 2 N, O and/or S atoms,
• Z is H, CF3, NO2, Hal, OH, NH2, NHA or NA2,
• A is alkyl having 1 to 6 C atoms,
• Ar phenyl which is mono- or disubstituted by Z,
• Hal is F, Cl, Br or I,
• n is 1 or 2.