Quinolin-4-yl derivatives

A compound of formula I:

• wherein
• is hydrogen, lower alkyl, lower alkoxy, hydroxy, amino, nitro, cyano, lower alkyl-amino, di-lower alkyl-amino or halogen;
• R2 is 2,3-dihydro-benzofuran-5-yl, chroman-6-yl, naphthalen-2-yl, indan-5-yl, lower alkenyl-phenyl, 5,6,7,8-tetrahydro-naphthalenyl, 2,3-dihydro-isoindol-2-yl, 1,2,3,4-tetrahydro-naphthalenyl, benzofuran-2-yl, benzo[b]thiophen-2-yl, lower alkyl-phenyl, 3,4-dihydro-1H-isoquinolin-2-yl or thiophen-3-yl, or is unsubstituted phenyl, or phenyl substituted by lower alkyl, lower alkoxy, halogen, trifluoromethyl, amino, lower alkyl-amino or di-lower alkyl-amino;
• R3 and R4 are independently from each other hydrogen or lower alkyl;
• R5 is hydrogen, lower alkyl, —CH2OH or —CH2NR6R7;
• R6 and R7 are independently from each other hydrogen, lower alkyl, —(CH2)n-phenyl, cycloalkyl, —(CH2)m-morpholinyl or form together with the N-atom a saturated ring with 4-6 C-atoms;
• n is 0-3;
• m is 2 or 3;
• X is —NR8— or —O—;
• or
• X and R5 are together >N(CH2)2—;
• or
• X and R3 are together >N(CH2)3—;
• and
• R8 is hydrogen or lower alkyl;
• or a pharmaceutically acceptable acid addition salt thereof, with the exception of the following compounds
• (6-chloro-2-phenyl-4-quinolinyl)-(+)-2-aminobutanol,
• (6-methyl-2-phenyl-4-quinolinyl)-(+)-2-aminobutanol,
• (6-methoxy-2-phenyl-4-quinolinyl)-(+)-2-aminobutanol and
• (8-methoxy-2-phenyl-4-quinolinyl)-(+)-2-aminobutanol.