Compounds useful for inhibition of farnesyl protein transferase

A compound of the formula:

• or a pharmaceutically acceptable salt or solvate thereof, wherein:
• a represents N or NO—;
• R1 and R3 are the same or different halo atom;
• R2 and R4 are selected from H and halo, provided that at least one of R2 and R4 is H;
• the dotted line (---) represents an optional bond;
• X is N, and the optional bond to X is absent;
• T is a substituent selected from:
• wherein:
• A represents —(CH2)b—;
• B represents —(CH2)d—;
• b and d are independently selected from:
• 0, 1, 2, 3, or 4 such that the sum of b and d is 3 or 4;
• and
• Y is selected from:
• O, S, SO, or SO2;
• wherein:
• D represents —(CH2)e—;
• E represents —(CH2)f—;
• e and f are independently selected from:
• 0, 1, 2, or 3 such that the sum of e and f is 2 or 3;
• and
• Z is O;
• wherein:
• F represents —(CH2)g—;
• G represents —(CH2)h—;
• U represents —(CH2)i—;
• h represents 1, 2, or 3;
• g and i are independently selected from:
• 0, 1 or 2 such that the sum of h, g and i is 2 or 3;
• and
• V and W are independently selected from O, S, SO, or SO2;
• wherein:
• the dotted line (---) represents an optional bound;
• k is 1 or 2 such that when the optional bond is present k represents 1, and when the optional double bond is absent then k represents 2;
• R5, R6, R7 and R8 are the same alkyl or
• R5 and R7 are the same alkyl and
• R6 and R8 are H;
• wherein:
• the dotted lines (---) represent optional bonds 1 and 2 such that optional bonds 1 and 2 are both present, or optional bonds 1 and 2 are both absent;
• Y represents O, S, SO, or SO2;
• wherein:
• Y represents O, S, SO, or SO2;
• wherein:
• R9 is selected from:
• —CN, —CO2H, or —C(O)N(R10)2;
• Y represents O;
• each R10 is the same or diferent alkyl group;
• wherein:
• I represents —(CH2)m—;
• m represents 2 or 3;
• Y represents O, S, SO, or SO2;
• and
• R11 represents alkyl.