US 6,440,971 B1 · Binuclear complex

Abstract

A binuclear DNA-threading transition metal complex with the general formula: (L1)-M1-(D1-B-D2)-M2-(L2) wherein D1-B-D2 is a bridging ligand; D1 is a polycyclic heteroaromatic ligand in which aza nitrogens can form a bidentate or tridentate chelate with Ml; D2 is any bi- or oligodentate ligand co-ordinated to the transition metal M2; B is any appropriately substituted chain of at least two atoms; M1 is a transition metal ion with octahedral co-ordination sphere; M2 is any transition metal ion; L1 comprises a set of 1-3 ancillary ligands that saturate the remaining co-ordination sphere of M1; and L2 comprises a set of 1-4 ancillary ligands that saturate the remaining co-ordination sphere of M2. An example of the complex according to the invention is shown in the FIG. 1. The complex according to the invention is useful for treatment of different diseases, such as cancer and infections.

Claims24

Dependent claims

A binuclear DNA-threading transition metal complex with the general formula

(L1)-M1-(D1-B-D2)-M2-(L2)
wherein:
D1-B-D2 is a bridging ligand;
D1 and/or D2 are a substituent having an optionally substituted cyclopentadipyrido[b:3,2-h:
2′,3′-j]phenazine-12-carboxylic acid;
B, covalently linking the ring system D1 to D2, is any appropriately substituted chain of at least two atoms;
M1 is a transition metal ion with octahedral co-ordination sphere that is capable of forming substitution-inert co-ordination bonds to the D1 moiety of the bridging ligand as well as to at least one of the bi- or polydentate ligands of set L1;
M2 is any transition metal ion;
and
L1 and/or L2 are a substituent having pyridyl groups, said pyridyl groups selected from the group consisting of 2,2′-bipyridine, 4,4′-dimethyl-2,2′-bipyridine and 2,2′,6′2″-terpyridine.

7 more elements

Dependencies are inferred from the claim text.

Binuclear complex

Life of this patent

Binuclear complex

Life of this patent

Abstract

Claims24