Pharmaceutical compositions and methods for use

The pharmaceutical composition incorporating a carrier and a compound of the formula

• wherein Q is (CH2)u, Q′ is (CH2)y, Q″ is (CH2)x, Q′″ is (CH2)x, and Q″″ is (CH2)y where u, v, w and x are individually 0, 1, 2, 3 or 4 ad y is 1 or 2, j is from 1 to 10, R is hydrogen or lower alkyl, Cy is an aromatic ring of the formula
• wherein X and X′ are nitrogen and X″ is nitrogen, nitrogen bonded to oxygen, or carbon bonded to a substituent species, and Z, A and A′ are, independently, hydrogen or a non-hydrogen substituent species selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, heterocyclyl, substituted heterocyclyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, halo, —NR′R″, —CF3, —OH, —CN, —NO2, —C2R′, —SH, —SCH3, —N3, —SO2CH3, —OR′, —SR′, —(═O)NR′R″, —NR′C(═O)R′, —C(═O)R′, —C(═O)OR′, —(CH2)qOR′, —OC(═O)R′, —(CR′R″)qOCH2C2R′, —(CR′R″)4C(═O)R′, —O(CR′R″)qC(═O)R′, —C2(CR′R″)qOR′, —(CR′R″)qNR′R″, —OC(═O)NR′R″and —NR′C(═O)OR′ where R′ and R″ are individually hydrogen or lower alkyl, an aromatic group-containing species or a substituted aromatic group-containing species, and q is an integer from 1 to 6, and a carrier,
• wherein the compound is a 2.2.1 bicycloheptane,
• wherein the aromatic group containing species is selected from the group consisting of pyridinyl, quinolidinyl, pyrimidinyl, phenyl, substituted phenyl and benzyl, and
• wherein the term substituted refers to the same list of substituents described above with respect to A and A′.

A compound of the formula:

• wherein Q is (CH2)u, Q′ is (CH2)v, Q″ is (CH2)x, Q′″ is (CH2)yand Q″″ is (CH2)y where u, v, w and x are individually 0, 1, 2, 3 or 4 and y is 1 or 2, j is from 1 to 10, R is hydrogen or lower alkyl, Cy is an aromatic ring of the formula
• wherein X′ and X″ are nitrogen and X is nitrogen, nitrogen bonded to oxygen, or carbon bonded to a substituent species, and Z, A and A′ are, independently, hydrogen or a non-hydrogen substituent species selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, heterocyclyl, substituted heterocyclyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, arylalkyl, substituted arylalkyl, halo, —NR′R″, —CF3, —OH, —CN, —NO2, —C2R′, —SH, —SCH3, —N3, —SO2CH3, —OR′, —SR′, —C(═O)NR′R″, —NR′C(═O)R′, —C(═O)R′, —C(═O)OR′, —(CH2)qOR′, —OC(═O)R′, —(CR′R″)qOCH2C2R′, —(CR′R″)qC(═O)R′, O(CR′R″)qC(═O)R′, —C2(CR′R″)qOR′, —(CR′R″)qNR′R″, —OC(═O)NR′R″ and —NR′C(═O)OR′ where R′ and R″ are individually hydrogen or lower alkyl, an aromatic group-containing species or a substituted aromatic group-containing species, and q is an integer from 1 to 6,
• wherein the compound is a 2.2.1 bicycloheptane.
• wherein the aromatic group containing species is selected from the group consisting of pyridinyl, quinolidinyl, pyrimidinyl, phenyl, substituted phenyl and benzyl, and
• wherein the term substituted refers to the same list of substituents described above with respect to A and A′.