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US 6,440,954 B1Granted
Inhibition of vascular smooth muscle cell proliferation
AssigneePresident and Fellows of Harvard College
InventorsCarol Haber, Wen-Sen Lee
Life of this patent
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Abstract
Methods of treating a mammal having a condition characterized by vascular smooth muscle cell proliferation, where the mammal is treated with progesterone or an agonist thereof. Also disclosed are methods of screening compounds useful for inhibiting vascular smooth muscle cell proliferation.
Claims11
A method of treatment comprising:
- identifying a mammal that is suspected of having, or at risk of having, a condition characterized by vascular smooth muscle cell proliferation and that is not being treated with estrogen or an agonist thereof;
- and
- administering to the mammal, an amount of progesterone effective to decrease vascular smooth muscle cell proliferation in the mammal, wherein said condition is selected from the group consisting of transplant arteriosclerosis, atherosclerosis, and angioplasty restenosis, aorta-coronary bypass stenosis.
A method of inhibiting proliferation of a mammalian vascular smooth muscle cell, comprising contacting said cell with progesterone in the absence of estrogen or an agonist thereof.
Dependencies are inferred from the claim text.