Phosphono-carboxylate compounds for treating amyloidosis
AssigneeQueen's University at Kingston
InventorsWalter A. Szarek, Xianqi Kong, Gregory R. J. Thatcher, Boris Gorine
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Abstract
Therapeutic compounds and methods for modulating amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is modulated by the administration to a subject of an effective amount of a therapeutic compound comprising a phosphonate group and a carboxylate group, a congener thereof, or a pharmaceutically acceptable salt or ester thereof. In preferred embodiments, an interaction between an amyloidogenic protein and a basement membrane constituent is modulated.
Claims20
A method for preparing a compound represented by the formula:
- in which R is alkyl or aryl, and R′ is hydrogen, alkyl, or aryl;
- the method comprising:
- reacting an ester of a carbonylphosphono diacid halide with a disilylether of a vicinal diol, under conditions such that a compound of said formula is prepared.
A compound represented by the formula:
- wherein G is hydrogen or one of more substituents on the aryl ring and the L is a substituted alkyl group.
A method of synthesizing a compound represented by the formula
- wherein
- G is hydrogen or one or more substituents on the aryl ring and the L is a hydroxy substituted alkyl group;
- the method comprising reacting an ester of a carbonylphosphono diacid halide with a disilylether of a vicinal diol, under conditions such that the compound of said formula is prepared.
Dependencies are inferred from the claim text.