Method for treating occlusive peripheral vascular disease and coronary disease
AssigneeThe Regents of the University of California
InventorsHal V. Barron, Elias Botvinick
Life of this patent
Estimating the term…
Abstract
Compositions and methods for treatment of occlusive peripheral vascular disease and coronary disease are disclosed. The compositions and methods allow treatment of diseases associated with occlusion of coronary vessels, for example, by promoting growth of new blood vessels, i.e., angiogenesis and/or by recruitment of collaterals. The methods involve the co-administration of an adenosine A2 receptor agonist, e.g., adenosine, and heparin and/or a heparin-like substance over a period of several days. In particular, this invention is applicable to improving collateral coronary circulation in patients suffering from myocardial infarction.
Claims16
A method for treatment of occlusive peripheral vascular disease, coronary disease and disorders associated with these diseases in a patient in need thereof comprising co-administration of adenosine and heparin and/or a heparin-like substance in low, daily dosages for a week or more, wherein the heparin-like substance is selected from the group consisting of chondroitin sulfates, dermatan sulfates, heparan sulfates, low molecular mass heparin fragments, heparin fractions, heparin salts, and mixtures thereof.
A pharmaceutical formulation comprising adenosine and heparin and/or a heparin-like substance in a pharmaceutically acceptable carrier, wherein the heparin-like substance is selected from the group consisting of chondroitin sulfates, dermatan sulfates, heparan sulfates, low molecular mass heparin fragments, heparin fractions, heparin salts, and mixtures thereof.
Dependencies are inferred from the claim text.