Crystalline forms

#This invention relates to new solid state forms of a drug, to pharmaceutical compositions containing them, and to processes for obtaining them.

#In the formulation of drug compositions, it is important for the drug substance to be in a form in which it can be conveniently handled and processed. This is of importance, not only from the point of view of obtaining a commercially viable manufacturing process, but also from the point of view of subsequent manufacture of pharmaceutical formulations (e.g. oral dosage forms such as tablets) comprising the active compound.

#Further, in the manufacture of oral drug compositions, it is important that a reliable, reproducible and constant plasma concentration profile of drug is provided following administration to a patient. This is of particular importance in the manufacture of compositions comprising antithrombotic agents.

#The invention is illustrated, but in no way limited, by the following examples, with reference to the enclosed figures in which:

#FIG. 1 shows a X-ray powder diffractogram for the crystalline form of EtO2C—CH2—(R)Cgl—Aze—Pab—OH obtained by way of Example 1.

#FIG. 2 shows a X-ray powder diffractogram for the crystalline form of EtO2C—CH2—(R)Cgl—Aze—Pab—OH monohydrate obtained by way of Example 6.