Angiogenically effective unit dose of FGF-2 and method of use

A method for treating a human patient for coronary artery disease, comprising administering a single unit dose of a recombinant fibroblast growth factor-2 (FGF-2) or an angiogenically active fragment or an angiogenically active mutein thereof into one or more coronary vessels or into a peripheral vein in a human patient in need of treatment for coronary artery disease, said unit dose comprising from about 0.008 mg to 7.2 mg of said recombinant FGF-2 or said angiogenically active fragment or said angiogenically active mutein thereof.

A method for inducing angiogenesis in a heart Of a human patient, comprising administering a single unit dose of a recombinant fibroblast growth factor-2 (FGF-2) or an angiogenically active fragment or an angiogenically active mutein thereof into one or more coronary vessels or into a peripheral vein in a human patient in need of treatment for coronary artery disease, said unit dose comprising from about 0.008 mg to 7.2 mg of said recombinant FGF-2 or said angiogenically active fragment or said angiogenically active mutein thereof.

A method for treating a human patient for a myocardial infarction, comprising administering a single unit dose of a recombinant fibroblast growth factor-2 (FGF-2) or an angiogenically active fragment or an angiogenically active mutein thereof into one or more coronary vessels or into a peripheral vein in said human patient, said unit dose comprising from about 0.008 mg to 7.2 mg of said recombinant FGF-2 or said angiogenically active fragment or said angiogenically active mutein thereof.

A method for providing a human patient with relief from symptoms of angina, comprising administering a single unit dose of a recombinant fibroblast growth factor-2 (FGF-2) angiogenically active fragment or an angiogenically active mutein thereof into one or more coronary vessels or into a peripheral vein in a human patient in need of relief from symptoms of angina, said unit dose comprising from about 0.008 mg to 7.2 mg of said recombinant FGF-2 or said angiogenically active fragment or said angiogenically active mutein thereof.

A method For treating a human patient for coronary artery disease, comprising administering a therapeutically effective amount of a recombinant) fibroblast growth factor-2 (FGF-2) or an angiogenically active fragment or an angiogenically active mutein thereof by infusion into one or more coronary vessels or into a peripheral vein in a human patient in need of treatment for said coronary artery disease, said therapeutically effective amount being about 0.2 μg/kg to 48 μg/kg of patient weight.

A method for treating a human patient for coronary artery disease comprising, administering a single unit dose of a recombinant fibroblast growth factor-2 (FGF-2) or an angiogenically active fragment or an angiogenically active mutein thereof by infusion into one or more coronary vessels or into a peripheral vein in a human patient in need of treatment for coronary artery disease, said unit dose comprising from about 0.008 mg to 7.2 mg of said recombinant FGF-2 or said angiogenically active fragment or said angiogenically active mutein thereof.

A method for inducing angiogenesis in a heart of a human patient, comprising administering a single unit dose of a recombinant fibroblast growth factor-2 (FGF-2) or an angiogenically active fragment or an angiogenically active mutein thereof by infusion into one or more coronary vessels or into a peripheral vein in a human patient in need of treatment for coronary artery disease, said unit dose comprising from about 0.008 mg to 7.2 mg of said recombinant FGF-2 or said angiogenically active fragment or said angiogenically active mutein thereof.

A method for treating a human patient for a myocardial infarction, comprising administering a single unit dose of a recombinant fibroblast growth factor-2 (FGF-2) or an angiogenically active fragment or an angiogenically active mutein thereof by infusion into one or more coronary vessels or into a peripheral vein in said human patient, said unit dose comprising from about 0.008 mg to 7.2 mg of said recombinant FGF-2 or said angiogenically active fragment or said angiogenically active mutein thereof.

A method for providing a human patient with relief from symptoms of angina comprising administering a single unit dose of a recombinant fibroblast growth factor-2 (FGF-2) or an angiogenically active fragment or an angiogenically active mutein thereof by infusion into one or more coronary vessels or into a peripheral vein in a human patient in need of relief from symptoms of angina, said unit dose comprising from about 0.008 mg to 7.2 mg of said recombinant FGF-2 or said angiogenically active fragment or said angiogenically active mutein thereof.