Antisense modulation of cellular apoptosis susceptibility gene expression
AssigneeIsis Pharmaceuticals, Inc.
InventorSusan M. Freier
Life of this patent
Estimating the term…
Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of cellular apoptosis susceptibility gene. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding cellular apoptosis susceptibility gene. Methods of using these compounds for modulation of cellular apoptosis susceptibility gene expression and for treatment of diseases associated with expression of cellular apoptosis susceptibility gene are provided.
Claims26
A compound 8 to 50 nucleobases in length targeted to nucleobases 202 to 2998 of a coding region or nucleobases 3093 to 3538 of a 3′-untranslated region of a nucleic acid molecule encoding human cellular apoptosis susceptibility gene (SEQ ID NO:3), wherein said compound specifically hybridizes with one of said regions and inhibits the expression of human cellular apoptosis susceptibility gene.
A compound up to 50 nucleobases in length consisting of at least an 8-nucleobase portion of SEQ ID NO:
- 17, 18, 19, 21, 22, 26, 27, 28, 29, 31, 33, 34, 35, 36, 37, 39, 41, 42, 43, 44, 45, 46, 47, 49, 50, 51, 52, 53, 54, 55, 56, 57, 60, 61, 63, 65, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83 or 84 which inhibits the expression of humane cellular apoptosis susceptibility gene.
Dependencies are inferred from the claim text.