Genes and proteins encoded thereby
AssigneesThe Scripps Research Institute, Janssen Pharmaceutica NV
InventorsPaul R. Russell, Jorge E. Vialard, Michael N. Boddy, Paul A. Shanahan, Antonia Lopez-Girona, Cecile-Marie D. D. Denis
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Abstract
The present invention encompasses novel mammalian cell cycle checkpoint genes/DNA repair genes, cDNA or genomic DNA, isolated nucleic acids corresponding thereto, expression vectors comprising said nucleic acids, host cells transformed with said expression vectors, pharmaceutical compositions and the formulation of such compositions comprising said nucleic acids or proteins expressed therefrom, methods for treating a cell using such nucleic acids, proteins or pharmaceutical compositions, and the use of such nucleic acids or proteins in formulating a pharmaceutical preparation.
Claims19
An isolated nucleic acid encoding a human Mus81 protein, said nucleic acid selected from the group consisting of:
- a) a nucleic acid encoding the amino acid sequence depicted in SEQ ID NO:
- 2;
- b) a nucleic acid encoding the amino acid sequence depicted in SEQ ID NO:
- 4;
- c) a nucleic acid encoding the amino acid sequence depicted in SEQ ID NO:
- 8;
- d) a nucleic acid encoding the amino acid sequence depicted in SEQ ID NO:
- 10;
- e) a nucleic acid sequence corresponding to that represented by nucleotides 23-1675 of the nucleotide sequence depicted in SEQ ID NO:
- 1;
- f) a nucleic acid sequence corresponding to that represented by nucleotides 185-1549 of the nucleotide sequence depicted in SEQ ID NO:
- 3;
- g) a nucleic acid sequence corresponding to that represented by nucleotides 26-1297 of the nucleotide sequence depicted in SEQ ID NO:
- 7;
- and
- h) a nucleic acid sequence corresponding to that represented by nucleotides 26-1681 of the nucleotide sequence depicted in SEQ ID NO:
- 9.
Dependencies are inferred from the claim text.