Alzheimer's disease secretase, APP substrates therefor, and uses therefor
OwnerMark E. Gurney, Michael J. Bienkowski +3inventors
InventorsMark E. Gurney, Michael J. Bienkowski, Robert L. Heinrikson, Luis A. Parodi, Riqiang Yan
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Abstract
The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
Claims19
An isolated polynucleotide comprising the nucleotide sequence set forth in SEQ ID NO:
- 7.
Dependencies are inferred from the claim text.