E6 targeted protein (E6TP1)
AssigneeNew England Medical Center
InventorsVimla Band, Qingshen Gao
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Abstract
The invention relates to a putative human tumor suppressor protein identified as a novel GAP protein, designated “E6TP1” (for E6-targeted protein), its nucleic acid and amino acid sequences, and methods of use thereof in the regulation of small G protein signaling pathways. In addition, methods of use of E6TP1 as a Therapeutic for treatment or prevention of carcinomas, especially HPV-associated carcinomas of anogenital origin, and other diseases is encompassed in the invention.
Claims19
An isolated nucleic acid encoding a human E6TP1 isoform, wherein said isoform binds to human papillomavirus E6 protein and comprises amino acids 489-819 of SEQ ID NO:2.
A host cell transformed with an expression vector, wherein said expression vector encodes an E6TP1 polypeptide comprising amino acids 489-819 of SEQ ID NO:2.
A host cell transformed with an expression vector, wherein said expression vector encodes an E6TP1 polypeptide comprising the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:4.
Dependencies are inferred from the claim text.