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US 6,440,694 B1Granted
TNF-related death ligand
AssigneePharmacia & Upjohn Company
InventorsMichael J. Bienkowski, Cynthia J. Mills, David A. Jones
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Abstract
The invention relates to a novel tumor necrosis factor (TNF) homolog designated herein as TNF-related death ligand (TRDL). Isolated nucleic acid molecules are provided which encode TRDL. TRDL polypeptides are also provided, as are methods for identifying agonists and antagonists of TRDL activity.
Claims19
An isolated nucleic acid molecule comprising a polynucleotide having a sequence selected from the group consisting of:
- (a) a nucleotide sequence encoding a TNF-related death ligand polypeptide having the complete amino acid sequence of SEQ ID NO:2 or SEQ ID NO:4;
- (b) a nucleotide sequence encoding the extracellular region of a TNF-related death ligand polypeptide having the amino acid sequence at about position 53 to about position 234 of SEQ ID NO:2, or about position 53 to about position 247 of SEQ ID NO:4;
- and
- (c) a nucleotide sequence fully complementary to the nucleotide sequence of (a) or (b).
1 more element
Dependencies are inferred from the claim text.