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AssigneesInstitut Pasteur, Centre National De La Recherche Scientifique
InventorsLuc Montangnier, Bernard Krust, Solange Chamaret, François Clavel, Jean-Claude Chermann, Françoise Barre-Sinoussi, Marc Alizon, Pierre Sonigo, Stewart Cole, Olivier Danos, Simon Wain-Hobson
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The molecular cloning and characterization of a novel human retrovirus, designated lymphadenopathy-associated virus, or LAV, is disclosed. LAV was originally isolated from a patient with acquired immune deficiency syndrome (AIDS). A cloned LAV complementary DNA (cDNA) was used to screen a library of recombinant phages constructed from the genomic DNA of LAV-infected T lymphocytes. The nucleotide sequence of an insert obtained from the recombinant phage clone λJ19 was ascertained through M13 shotgun cloning and the dideoxy chain termination sequencing method. The env coding region was identified and various hydrophilic peptides obtained therefrom. These peptides correspond to amino acids 551-577, 594-603, 621-630, 657-679, and 719-758 of the LAV envelope glycoprotein. These peptides should provide suitable diagnostic reagents for the detection LAV-specific antibodies and for the generation of LAV-specific immunological reagents.
A chemically synthesized env peptide of Human Immunodeficiency Virus (HIV) of less than 150 amino acid residues, wherein the peptide comprises the sequence:
A chemically synthesized env peptide of Human Immunodeficiency Virus (HIV) of less than 150 amino acid residues, wherein the peptide comprises the sequence:
A chemically synthesized env peptide of Human Immunodeficiency Virus (HIV) of less than 150 amino acid residues, wherein the peptide comprises the sequence:
A chemically synthesized env peptide of Human Immunodeficiency Virus (HIV) of less than 150 amino acid residues, wherein the peptide comprises the sequence:
A chemically synthesized env peptide of Human Immunodeficiency Virus (HIV) of less than 150 amino acid residues, wherein the peptide comprises the sequence:
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