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US 6,440,460 B1Granted
Pharmaceutical compositions containing buffered ortho ester polymers
AssigneeAllergan Sales, Inc.
InventorsRobert Gurny, Monia Zignani, Cyrus Tabatabay
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Abstract
A pharmaceutical composition for the controlled release of therapeutic agents from carboxylic acid ortho ester polymers contains a pharmaceutically acceptable salt of an acid, which together with the acid R1-COOH liberated from the decomposition of the ortho ester polymer forms a buffer system in a physiologically acceptable pH range.
Claims8
A pharmaceutical composition for the controlled release of therapeutic agents from a polymer matrix comprising:
- a) the therapeutic agent or a combination of therapeutic agents to be administered;
- b) a bioerodible carboxylic acid ortho ester polymer consisting essentially of monomer repeating units of the partial formula:
- wherein R1 represents hydrogen or C1-4-alkyl and A represents a hydrocarbon chain of the formula
- wherein Ra, Rb, and Rc independently represent hydrogen or C1-4-alkyl, and m and n independently represent zero or integers from one to three;
- c) a pharmaceutically acceptable salt of an acid, which together with the acid R1-COOH being liberated from the decomposition of the ortho ester polymer (I) forms a buffer system in a physiologically acceptable pH range;
- and the following optional components;
- d) further pharmaceutically acceptable additives;
- and or
- e) a pharmaceutically acceptable carrier liquid.
6 more elements
Dependencies are inferred from the claim text.