Paroxetine maleate polymorph and pharmaceutical compositions containing it
AssigneeMedichem, S.A.
InventorsAlberto Stampa Diez del Corral, Jordi Bosch Lladó, Elias Molins Grau, Maria del Carmen Onrubia Miguel
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Abstract
The form B of paroxetine maleate polymorph is characterized by determined data of X ray diffraction: it has a chemical stability which is superior to that of the form A of paroxetine maleate. This superior stability enables to use the new polymorph for the fabrication of medicaments intended to the treatment of troubles related to dysfunctions of the central nervous system. The process for producing the paroxetine maleate comprises the preparation of paroxetine maleate solution and a consequent precipitation.
Claims9
Paroxetine maleate polymorph in Form B showing substantially the following X-ray diffraction data:
- d l (%) 17.11 63 8.61 5 6.35 18 5.73 100 5.57 46 4.99 11 4.74 11 4.57 7 4.32 19 3.65 25 3.54 10 3.35 20 3.18 12 3.09 8 2.87 7 d = spacing in A;
- l (%) = relative intensity ≧ 5%
- and an infra red spectrum in KBr tablet substantially coincident with the one shown in FIG. 2.
Dependencies are inferred from the claim text.