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US 6,440,428 B1Granted
Podophyllotoxin preparation containing triglycerides
AssigneeAnalytecon SA
InventorsKurt Leander, Jan Gunzinger, Börje Rosen
Life of this patent
Estimating the term…
Abstract
The invention refers to new pharmaceutical preparations for the treatment of psoriasis and condyloma acuminata, and containing podophyllotoxin in combination with a liquid triglyceride.
Claims12
A cream for the treatment of condyloma acuminata which comprises:
- a fatty phase containing 8 parts by weight of polyethylene glycol (7) stearyl ether, polyethylene glycol (10) stearyl ether and stearyl alcohol, 2 parts by weight hexadecanol, 2 parts by weight octadecanol, 2 parts by weight isopropyl myristate, 3 parts by weight liquid paraffin, 10 parts by weight fractionated coconut oil, and 0.008 parts by weight butylhydroxyanisole;
- an aqueous phase containing 71.642-72.632 parts by weight water, 0.10 parts by weight methylparaben, 0.03 parts by weight propylparaben, 0.1 parts by weight 1M phosphoric acid, and 0.12 parts by weight sorbic acid;
- and
- 0.01-1 parts by weight podophyllotoxin as active ingredient.
1 more element
A cream for the treatment of psoriasis which comprises:
- a fatty phase containing 22 parts by weight of petrolatum, ozokerite, hydrogenated castor oil, glyceryl oleate, polyglyceryl (4) isostearate and t-butylhydroxytoluene, 10 parts by weight fractionated coconut oil, and 3 parts by weight isopropyl myristate;
- an aqueous phase containing 58.15-59.13 parts by weight water, 0.10 parts by weight methylparaben, 0.03 parts by weight propylparaben, 5 parts by weight propylene glycol, 0.1 parts by weight 1M phosphoric acid, 0.5 parts by weight MgSO4×7 H2O, and 0.12 parts by weight sorbic acid;
- and 0.02-1 parts by weight podophyllotoxin as active ingredient.
A cream for the treatment of condyloma acuminata or psoriasis which comprises:
- a fatty phase containing 8 parts by weight of polyethylene glycol (7) stearyl ether, polyethylene glycol (10) stearyl ether and stearyl alcohol, 2 parts by weight hexadecanol, 2 parts by weight octadecanol, 15 parts by weight fractionated coconut oil, 2 parts by weight liquid paraffin, and 0.008 parts by weight butylhydroxyanisole;
- an aqueous phase containing 69.642-70.622 parts by weight water, 0.10 parts by weight methylparaben, 0.03 parts by weight propylparaben, 0.1 parts by weight 1M phosphoric acid, and 0.12 parts by weight sorbic acid;
- and
- 0.02-1 part by weight podophyllotoxin as active ingredient.
1 more element
A cream for the treatment of condyloma acuminata or psoriasis which comprises:
- a fatty phase containing 3 parts by weight polyethylene glycol (2) stearyl ether, 2 parts by weight polyethylene glycol (21) stearyl ether, 2 parts by weight hexadecanol, 1.5 parts by weight stearic acid, 9 parts by weight fractionated coconut oil, and 0.008 parts by weight butylhydroxyanisole;
- an aqueous phase containing 81.142-82.122 parts by weight water, 0.10 parts by weight methylparaben, 0.03 parts by weight propylparaben, 0.1 parts by weight 1M phosphoric acid, and 0.12 parts by weight sorbic acid;
- and
- 0.02-1 parts by weight podophyllotoxin as active ingredient.
1 more element
A cream for the treatment of condyloma acuminata which comprises:
- a fatty phase containing 5 parts by weight polyethylene glycol (5) glyceryl stearate, 2 parts by weight hexadecanol, 1.5 parts by weight stearic acid, 3 parts by weight fractionated coconut oil, 2 parts by weight liquid paraffin, and 0.008 parts by weight butylhydroxyanisole;
- an aqueous phase containing 81.142-82.132 parts by weight water, 0.10 parts by weight methylparaben, 0.03 parts by weight propylparaben, 0.1 parts by weight 1M phosphoric acid, 4 parts by weight propylene glycol, and 0.12 parts by weight sorbic acid;
- and
- 0.01-1 parts by weight podophyllotoxin as active ingredient.
1 more element
A cream for the treatment of condyloma acuminata or psoriasis which comprises:
- a fatty phase containing 10 parts by weight polyethylene glycol-glycerol-sorbitan isostearate, 3 parts by weight isopropyl myristate, 10 parts by weight liquid paraffin, 12 parts by weight fractionated coconut oil, and 0.008 parts by weight butylhydroxyanisole;
- an aqueous phase containing 59.142-60.122 parts by weight water, 4 parts by weight propylene glycol, 0.5 parts by weight MgSO4×7 H2O, 0.1 parts by weight 1M phosphoric acid, 0.10 parts by weight methylparaben, 0.03 parts by weight propylparaben, and 0.12 parts by weight sorbic acid;
- and
- 0.02-1 parts by weight podophyllotoxin as active ingredient.
1 more element
Dependencies are inferred from the claim text.