High molecular weight major outer membrane protein of moraxella
AssigneeAventis Pasteur Limited
InventorsKen Sasaki, Robin E. Harkness, Sheena M. Loosmore, Pele Chong, Michel H. Klein
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Abstract
An isolated and purified outer membrane protein of a Moraxella strain, particularly M. catarrhalis, having a molecular mass of about 200 kDa, is provided. The about 200 kDa outer membrane protein as well as nucleic acid molecules encoding the same are useful in diagnostic applications and immunogenic compositions, particularly for in vivo administration to a host to confer protection against disease caused by a bacterial pathogen that produces the about 200 kDa outer membrane protein or produces a protein capable of inducing antibodies in a host specifically reactive with the about 200 kDa outer membrane protein.
Claims6
An isolated and purified outer membrane protein of a Moraxella catarrhalis strain having an apparent molecular mass of about 200 kDa, as determined by SDS-PAGE, characterized by an amino acid sequence selected from the group consisting of:
- (a) an amino acid sequence containing SEQ ID NO:3;
- (b) an amino acid sequence encoded by SEQ ID NO:1 or 2;
- (c) an amino acid sequence containing SEQ ID NO:8;
- (d) an amino acid sequence containing an amino acid sequence encoded by SEQ ID NO:7;
- (e) an amino acid sequence containing SEQ ID NO:6;
- (f) an amino acid sequence containing SEQ ID NO:9;
- and
- (g) an amino acid sequence containing SEQ ID NO:10.
A peptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NO:9 and SEQ ID NO:10.
Dependencies are inferred from the claim text.