Antibodies to argatroban derivatives and their use in therapeutic and diagnostic treatments
AssigneeConjuChem, Inc.
InventorsKaren Thibaudeau, Dominique Blanchard, Dominique P. Bridon, Alan M. Ezrin, Margaret Hardy, Nissab Boudjellab
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Abstract
Antibodies to a therapeutic agent and its derivatives and conjugates are disclosed, including antibodies to argatroban and its derivatives and conjugates. The antibodies are useful as reagents in assays and diagnostic kits for determining the concentration of a therapeutic agent or its derivatives and conjugates in biological samples, and further have therapeutic uses in treatment for potential toxicity associated with stable therapeutic conjugates and derivatives, both in vivo and ex vivo.
Claims10
An isolated monoclonal antibody that specifically binds argatroban and argatroban derivatives, wherein said monoclonal antibody is produced by hybridoma cell line 9C10 having A.T.C.C. Accession No. PTA-3772, wherein said argatroban derivatives are selected from the group consisting of argatroban-C6-NHS, argatroban-C12-NHS, argatroban-C13-maleimide, argatroban-C21-PE-maleimide, and argatroban-C18-maleimide.
Dependencies are inferred from the claim text.