Vaccines against cancer and infectious diseases
AssigneeImmunomedics, Inc.
InventorsDavid M. Goldenberg, Hans J. Hansen
Life of this patent
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Abstract
A method of stimulating an immune response in a human against malignant cells or an infectious agent comprises the step of administering to the human an immunogenic amount of a primate anti-idiotype antibody or antibody fragment that acts as an immunogenic functional mimic of an antigen produced by or associated with a malignant cell or an infectious agent. Sub-human primate anti-idiotype antisera, especially from baboons, are preferred. Such anti-idiotype antibodies are used to make vaccines for inducing preventive immunity or a therapeutic immune response against tumors, viruses, bacteria, rickettsia, mycoplasma, protozoa, fungi and multicellular parasites.
Claims26
A method of stimulating an immune response in a human against malignant cells or an infectious agent, which comprises the step of administering to said human an immunogenic amount of a baboon anti-idiotype antibody or antibody fragment that acts as an immunogenic functional mimic of an antigen that is a marker for a malignant cell or an infectious agent.
An antitumor or antipathogen vaccine, comprising an immunogenic amount of a baboon anti-idiotype antibody or antibody fragment that is an immunogenic functional mimic of an antigen that is a marker for a malignant cell or infectious agent, and a physiologically acceptable vaccine vehicle.
Dependencies are inferred from the claim text.