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US 6,440,389 B1Granted
Fluorescent agents for real-time measurement of organ function
AssigneeThe General Hospital Corporation
InventorCarlos Rabito
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Abstract
A fluorescent agent for monitoring organ function, such as glomerular filtration, renal blood flow, or hepatic function. The agent is injected into a subject and the fluorescence monitored in vivo via time-resolved fluorescent techniques. The agent is a lanthanide ion chelated to a polyaminopolyacetic acid analog. A new clearance agent is also proposed based on a tetraazamacrocycle. Such a clearance agent also finds applications in other fields where fluorescence detection is exploited.
Claims14
A method of detecting a clearance function in a subject comprising:
- providing an electroluminescent agent in a circulatory system of the subject;
- irradiating a tissue site with electromagnetic radiation having sufficient energy and intensity to be absorbed by the agent;
- detecting the intensity of emission from the tissue site;
- and
- repeating the step of detecting at known time intervals, wherein:
- the agent comprises an electroluminescent moiety conjugated with
- wherein S is a five-membered cyclic organic moiety having at least one atom selected from oxygen and nitrogen, and wherein R is an organic acid.
4 more elements
Dependencies are inferred from the claim text.