Methods and compositions for performing molecular separations
AssigneeCaliper Technologies Corp.
InventorRobert S. Dubrow
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Abstract
The present invention provides methods of electrophoretically separating macromolecular species, as well as compositions and systems useful in carrying out such methods. Specifically, the methods of the present invention comprise providing a substrate that has at least a first capillary channel disposed therein. The surface of the channel has a first surface charge associated therewith, and is filled with a water soluble surface adsorbing polymer solution that bears a net charge that is the same as the charge on the capillary surface.
Claims84
A method of manufacturing a microfabricated channel system, the method comprising:
- providing a device comprising at least one microchannel;
- and
- disposing a polymer in the at least one microchannel, the polymer comprising a net charge, the net charge being of the same type as at least one surface of the microchannel.
A device, comprising:
- at least one microchannel, the microchannel comprising a polymer disposed therein, the polymer comprising a net charge, the net charge being of the same type as at least one surface of the microchannel.
Dependencies are inferred from the claim text.