Malleable paste with high molecular weight buffered carrier for filling bone defects

A sterile formable bone putty composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing mixture of demineralized lyophilized allograft bone powder with a particle size ranging from about 250 to about 710 microns in sodium hyaluronate with an ionic salt based phosphate buffer carrier causing the composition to have a pH ranging between about 6.8 and about 7.4, the sodium hyaluronate component having a molecular weight of at least six hundred and sixty thousand Daltons and a stable viscosity ranging from 6,000 to about 275,000 cps at a temperature range of 22° to 37° C., the bone content of the carrier ranging in weight from about 20% to less than 50% total weight of the composition.

A formable bone putty composition for application to a bone defect site to promote new bone growth at the site comprising a new bone growth inducing demineralized lyophilized allograft bone powder with a particle size ranging from about 250 to about 710 microns in a high molecular weight sodium hyaluronate and saline phosphate buffer carrier, the bone demineralized content of the composition ranging from about 30% to about 35% by weight and the high molecular weight sodium hyaluronate component being sterile and constituting a percentage of the carrier not in excess of 5% of the weight of the carrier and has a molecular weight greater than 600,000 Daltons.

A sterile formable bone gel composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing amount of demineralized lyophilized allograft bone powder with a particle size ranging from about 250 to about 800 microns in a high molecular weight sodium hyaluronate having a molecular weight of at least about six hundred and sixty thousand Daltons in saline phosphate buffer carrier with the sodium hyaluronate component comprising about 75% to about 2.5% of the carrier weight and having a viscosity of about 1,800 to 13,000 cps, the bone powder content of the composition ranging from about 25% to about 30% with said composition having an osmolality ranging from about 280 to about 340 mOsmol/Kg.

A sterile formable bone putty composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of demineralized lyophilized allograft bone powder with a particle size ranging from about 250 to about 710 microns in a hydrogel ionic salt based phosphate buffer carrier, the hydrogel component comprising sodium hyaluronate and its derivatives and ranging from about 2.0% to about 5.0% by weight of the carrier and having a molecular weight of at least 600,000 Daltons, said composition having a pH ranging from 6.8 to 7.4.

A sterile formable bone putty composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing amount of demineralized lyophilized allograft bone powder in a high molecular weight hydrogel in saline phosphate buffer solution carrier, said hydrogel comprising an acid mucopolysaccharide having a molecular weight of at least 700,000 Daltons, the bone amount content of the composition ranging from about 30% to about 38% by weight and the high molecular weight hydrogel ranging from about 2.0%to about 5.0% by weight of the carrier, said composition having an osmolality ranging from 280-340 mOsmol/Kg.

A sterile formable bone putty composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing amount of demineralized lyophilized allograft bone powder in a high molecular weight hydrogel and saline phosphate buffer solution carrier, said hydrogel comprising an acid mucopolysaccharide having a molecular weight of at least 600,000 Daltons, the bone amount content of the composition ranging from about 30% to about 35% by weight and the high molecular weight hydrogel ranging from about 2.0% to about 4.0% by weight of the carrier, said composition having a pH ranging from about 7.2 to about 7.4.

A sterile formable bone putty composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing amount of demineralized lyophilized human allograft bone powder carrier in a high molecular weight hydrogel and saline phosphate buffer solution carrier, said hydrogel comprising an sodium hyaluronate having a molecular weight of at least 3,000,000 Daltons, the bone amount content of the composition ranging from about 30% to about 38% by weight and the high molecular weight hydrogel ranging from about 0.25% to about 1.5% by weight of the carrier, said composition having a pH ranging from about 6.8 to about 7.4.