Use of fumaric acid derivatives
AssigneeFumapharm AG
InventorsRajendra Kumar Joshi, Hans Peter Strebel
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Abstract
Disclosed is a method of treating auto-immune diseases by the administration of certain fumaric acid monoalkyl esters as salts or free acids thereof either alone or in combination with a dialkyl fumarate.
Claims23
A method for treating a patient suffering from an auto immune disease selected from the group consisting of graft-versus host reactions, juvenile diabetes, Hashimoto's thyroiditis, Grave's disease, systemic Lupus erythematosus (SLE), Sjogren's syndrome, pernicious anaemia and chronically active (=lupoid) hepatitis comprising:
- administering an effective amount of a compound of a sodium, potassium, calcium, magnesium, zinc or iron salt of a funaric acid monoalkyl ester of the general formula
- optionally in combination with dialkyl fumarate of the formula
- wherein A is a bivalent cation selected from the group consisting of Ca, Mg, Zn or Fe or a monovalent cation from the series consisting of potassium or sodium, respectively, and n denotes the numeral 1 or 2 depending on the type of cation, or administering at least one alkyl hydrogen fumarate compound of the general formula
- optionally in combination with dialkyl fumarate of the formula
- wherein each of R, R1 and R2 is C1-C5 alkyl and may be the same or different;
- and optionally, in combination with commonly used pharmaceutical excipients and vehicles.
A method for treating a patient suffering from an auto immune disease selected from the group consisting of polyarthritis, multiple sclerosis and graft-versus host reactions, juvenile diabetes, Hashimoto's thyroiditis, Grave's disease, systemic Lupus erythematosus (SLE), Sjogren's syndrome, pernicious anaemia and chronically active (=lupoid) hepatitis comprising:
- administering in the form of pellets or microtablets an effective amount of a compound of a sodium potassium, calcium, magnesium, zinc or iron salt of a fumaric acid monoalkyl ester of the general formula:
- optionally in combination with dialkyl funarate of the formula
- wherein A is a bivalent cation selected from the group consisting of Ca, Mg, Zn or Fe or a monovalent cation from the series consisting of potassium or sodium, respectively, and n denotes the numeral 1 or 2 depending on the type of cation, or administering at least one alkyl hydrogen fumarate compound of the general formula
- optionally in combination with dialkyl fumarate of the formula
- wherein each of R, R1 and R2 is C1-C5 alkyl and may be the same or different.
Dependencies are inferred from the claim text.