Selective neurokinin antagonists

A compound represented by the structural formula

• or a pharmaceutically acceptable salt thereof, wherein
• Ar1 and Ar2 are independently selected from the group consisting of
• X1 is —O—, —NR12—, —N(COR12)— or —N(SO2)R15—;
• R1, R2, R3 and R7 are each independently selected from the group consisting of H, C1-C6 alkyl, hydroxy(C1-C3)alkyl, C3-C6 cycloalkyl, —CH2F, —CHF2 and —CF3;
• or R1 and R2, together with the carbon to which they are attached, form a C3-C6 alkylene ring;
• each R6 is independently selected from H, C1-C6 alkyl, —OR13 or —SR12;
• n is 1;
• is
• X2 is —NR5—;
• Y is ═O;
• R5 is H or —(CH2)n1—G, wherein n1 is 0-5, G is H, —CF3, —CHF2, —CH2F, —OH, —O—(C1-C6 alkyl), —SO2R13, —O—(C3-C8 cycloalkyl), —NR13R14, —SO2NR13R14, —NR13SO2R15, —NR13COR12, —NR12(CONR13R14), —CONR13R14, —COOR12, C3-C8 cycloalkyl, R19-aryl,
• or when n1 is 0, R5 can also be —C(O)R13 or —C(S)R13;
• provided that G is not H when n1=0;
• X is —CF2—, —CH2— or —CR12F—;
• R8, R9 and R10 are independently selected from the group consisting of H, C1-C6 alkyl, C3-C8 cycloalkyl, —OR12, halogen, —CN, —NO2, —CF3, —CHF2, —CH2F, —OCF3, —OCHF2, —OCH2F, —COOR12, —CONR21R22, —NR21COR12, —NR21CO2R15, —NR21CONR21R22, —NR21SO2R15, —NR21R22, —SOO2NR21R22, —S(O)n5R15, R16-aryl and R19-heteroaryl;
• R11 is H, C1-C6 alkyl, C3-C8 cycloalkyl, —NO2, —CN, OH, —OR12, —O(CH2)n6R12, —(C1-C3)alkyl-C(O)NHR12, R19-aryl(CH2)n6— or R19-heteroaryl-(CH2)n6—;
• R4 and R12 are each independently selected from the group consisting of H, C1-C6 alkyl and C3-C8 cycloalkyl;
• R13 and R14 are independently selected from the group consisting of H, C1-C6 alkyl, C3-C8 cycloalkyl, or R19-aryl(CH2)n6—;
• R15 is C3-C6 alkyl, C3-C8 cycloalkyl or —CF3;
• R16 is 1 to 3 substituents independently selected from the group consisting of H, C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 alkoxy, halogen and —CF3;
• R19 is 1 to 3 substituents independently selected from the group consisting of H, C1-C6 alkyl, C3-C8 cycloalkyl, —OH, halogen, —CN, —NO2, —CF3, —CHF2, —CH2F, —OCF3, —OCHF2, —OCH2F, —O—(C1-C6 alkyl), —O—(C3-C8 cycloalkyl), —COOR12, —CONR21R22, —NR21R22, —NR21COR12, —NR21CO2R12, —NR21CONR21R22, —NR21SO2R15 and —S(O)n5R15;
• R21 and R22 are independently selected from the group consisting of H, C1-C6 alkyl, C3-C8 cycloalkyl and benzyl;
• n3 and n4 are independently 1-5, provided that the sum of n3 and n4 is 2-6;
• n5 is independently 0-2;
• and
• n6 is independently 0-3;
• wherein heteroaryl means a 5- to 10-membered single or benzofused aromatic ring comprising 1 to 4 heteroatoms independently selected from the group consisting of —O—, —S—, —N═ and —NH—, provided that the rings do not include adjacent oxygen and/or sulfur atoms.