Steroid sulfatase inhibitors and methods for making and using the same
AssigneesDuquesne University of the Holy Ghost, Kyowa Hakko Kogyo Co., Ltd.
InventorsPui-Kai Li, Chikara Murakata, Shiro Akinaga
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Abstract
Novel sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position. Methods for synthesizing these compounds and using them in the therapeutic and/or prophylactic treatment of a patient are also disclosed.
Claims19
A method of treating a patient for an estrogen dependent illness comprising administering to said patient an effective amount of a compound having the formula:
- wherein R1 and R2 are independently selected from hydrogen and a lower alkyl group having one to six carbons;
- R3 is:
- R4 and R5 are independently selected from hydrogen, straight or branched chain alkyl groups having one to fourteen carbons, and straight or branched chain alkoxy groups having one to six carbons and wherein X and Y are both carbons and the bond between X and Y is either single or double.
A compound having the formula
- wherein R1 and R2 are independently selected from hydrogen and a lower alkyl group having one to six carbons;
- and
- R8 is hydrogen, and R9 is a straight or branched alkanoyl group having one to eight carbons.
A method of treating a patient for an estrogen dependent illness comprising administering to said patient an effective amount of a compound having the formula:
- wherein R1 and R2 are independently selected from hydrogen and a lower alkyl group having one to six carbons;
- and
- R3 is
- R8 is hydrogen, and R9 is a straight or branched alkanoyl groups having one to right carbons.
Dependencies are inferred from the claim text.