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US 6,436,660 B1Granted
Identification of novel antimicrobial agents using metabolic oxidation-reduction indicator dyes
AssigneeXoma Technology Ltd.
InventorRoger G. Little, II
Life of this patent
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Abstract
Novel screening methods for identifying antimicrobial agents involving use of metabolic oxidation-reduction indicator dyes are provided.
Claims8
A method of identifying antimicrobal compound comprising the steps of:
- (a) contacting a microbial cell with a metabolic activity oxidation-reduction indicator dye in the presence and absence of test compound, and
- (b) detecting apparent increased metabolic activity in the presence of the test compound relative to metabolic activity in the absence of the test compound, despite onset of loss or reduction of microbial cell viability.
A method of identifying an antifungal compound comprising the steps of:
- (a) contacting a fungal cell with a metabolic;
- activity oxidation-reduction indicator dye in the presence and absence of test compound, and
- (b) detecting apparent increased metabolic activity in the presence of the test compound relative to metabolic activity in the absence of the test compound, despite onset of loss or reduction of fungal cell viability.
A method of identifying an antibacterial compound comprising the steps of:
- (a) contacting a bacterial cell with a metabolic activity oxidation-reduction indicator dye in the presence and absence of test compound, and
- (b) detecting apparent increased metabolic activity in the presence of the test compound relative to metabolic activity in the absence of the test compound, despite onset of loss or reduction of bacterial cell viability.
Dependencies are inferred from the claim text.