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US 6,436,397 B1Granted
Activated protein C formulations
AssigneeEli Lilly and Company
InventorsJeffrey Clayton Baker, Andrew David Carlson, Lihua Huang, Theodore Arsay Sheliga
Life of this patent
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Abstract
The present invention is broadly directed to a method for reducing autodegradation of activated protein C during processing and purification. The present invention provides aqueous activated protein C solutions and an improved method of processing of such solutions, comprising conducting such processing at an ionic strength of greater than 150 mM and at a pH of about 5.5 to less than 6.3.
Claims5
A lyophilized pharmaceutical formulation comprising recombinantly produced activated protein C and a bulking agent;
- said formulation having less than about 10% des(1-9) activated protein C and des(1-10) activated protein C by combined weight.
Dependencies are inferred from the claim text.