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US 6,432,986 B1Granted
Compositions, kits, and methods for inhibiting cerebral neurovascular disorders and muscular headaches
OwnerBruce H. Levininventor
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OwnerBruce H. Levininventor
Estimating the term…
Methods, kits, and compositions for inhibiting a cerebral neurovascular disorder or a muscular headache in a human patient are provided. The methods comprise intranasally administering to the patient a pharmaceutical composition comprising a local anesthetic, and preferably a long-acting local anesthetic ingredient. A composition useful for practicing the methods of the invention is described which comprises at least one local anesthetic in a pharmaceutically acceptable carrier, wherein the composition is formulated for intranasal delivery. Cerebral neurovascular disorders include migraine and cluster headache. Muscular headaches include tension headaches and muscle contraction headaches. A kit comprising the composition and an intranasal applicator and a method of systemically delivering a pharmaceutically active agent to an animal are also included in the invention.
A method of inhibiting a cerebral neurovascular disorder in a human patient, the method comprising dorsonasally administering to the patient over a period of time of less than about one half hour a composition comprising a long-acting local anesthetic other than 2-(diethylamino)-N-(2,6dimethylphenyl)acetamide or cocaine in an amount effective to anesthetize a dorsonasal nerve structure, whereby anesthetizing the dorsonasal nerve structure is effective, following completion of the administration of the composition, to inhibit the cerebral neurovascular disorder for greater than one hour.
A method of inhibiting a muscular headache in a human patient, the method comprising dorsonasally administering to the patient over a period of time of less than about one half hour a composition comprising a long-acting local anesthetic comprising a long-acting local anesthetic other than 2-(diethylamino)-N-(2,6dimethylphenyl)acetamide or cocaine in an amount effective to anesthetize a dorsonasal nerve structure, whereby anesthetizing the dorsonasal nerve structure is effective, following completion of the administration of the composition, to inhibit the muscular headache for greater than one hour.
Dependencies are inferred from the claim text.