Pyrazolecarboxylic acid derivatives, their preparation, pharmaceutical compositions containing them
AssigneeSanofi-Synthelabo
InventorsFrancis Barth, Philippe Camus, Serge Martinez, Murielle Rinaldi
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Abstract
N-Piperidino-5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethylpyrazole-3-carboxamide and its salts and solvates are powerful antagonists of the CB1 cannabinoid receptors. They are prepared by reacting a functional derivative of 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethylpyrazole-3-carboxylic acid with 1-aminopiperidine, optionally followed by salification.
Claims5
N-Piperidino-5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethylpyrazole-3-carboxamide, of formula:
- or a pharmaceutically acceptable salt and/or solvate thereof.
A process for preparing N-piperidino-5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethylpyrazole-3-carboxamide, or a pharmaceutically acceptable salt and/or solvate thereof, wherein a functional derivative of 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethylpyrazole-3-carboxylic acid, of formula:
- is treated with 1-aminopiperidine, in an organic solvent and in the presence of a base;
- and the compound thus obtained is optionally converted into one of its salts or one of the solvates thereof.
Dependencies are inferred from the claim text.