Active immunization using a siderophore receptor protein
AssigneeWillmar Poultry Company, Inc.
InventorsDaryll A. Emery, Darren E. Straub, Richard Huisinga, Beth A. Carlson
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Abstract
The invention provides a vaccine for immunizing poultry and other animals against infection by a gram-negative bacteria, and a method of immunizing an animal using the vaccine. The vaccine may contain purified siderophore receptor proteins derived from a single strain or species of gram-negative bacteria or other organism, which are cross-reactive with siderophores produced by two or more strains, species or genera of gram-negative bacteria. The invention further provides a process for isolating and purifying the siderophore receptor proteins, and for preparing a vaccine containing the proteins. Also provided is a method for diagnosing gram-negative sepsis.
Claims15
A method for enhancing weight gain performance in an avian specie, the method comprising:
- administering to the avian specie a vaccine composition comprising:
- (i) at least four different siderophore receptor proteins, wherein the siderophore receptor proteins stimulate production of antibodies that cross-react with siderophore receptor proteins of at least two different strains or species of gram-negative bacteria and wherein the siderophore receptor proteins are extracted from the outer membrane of a bacterium of the Enterobacteriaceae family;
- and
- (ii) a physiologically acceptable carrier.
Dependencies are inferred from the claim text.