Pharmacological drug combination in vagal-induced asystole
AssigneeEmory University
InventorJohn D. Puskas
Life of this patent
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Abstract
Controlled cessation of heart beat during coronary bypass surgery and other cardiac surgeries on a beating heart improves surgical technique, and is achieved typically by electrical stimulation of the vagus nerve and administration of a combination of drugs.
Claims25
A method of preparing a patient for asystole, comprising administration to the patient of an amount of a pharmaceutical composition comprising an acetylcholinesterase inhibitor, a β-adrenergic receptor blocker, and a calcium channel blocker, wherein the amount of the composition is effective to produce cardiac asystole upon stimulation of one or both vagus nerves.
A method for achieving controlled cardiac asystole in a patient, comprising administration to the patient of a pharmaceutical composition comprising an acetylcholinesterase inhibitor, a β-adrenergic receptor blocker, and a calcium channel blocker, and stimulation of one or both vagus nerves.
Dependencies are inferred from the claim text.