Surface treatment of medical device
AssigneeBausch & Lomb Incorporated
InventorsJay F. Künzler, David E. Seelye, Joseph C. Salamone
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Abstract
The invention provides a method for improving the wettability of a medical device, comprising the steps of: (a) providing a medical device formed from a monomer mixture comprising a hydrophilic monomer and a silicone-containing monomer, wherein said medical device has not been subjected to a surface oxidation treatment; (b) contacting a surface of the medical device with a solution comprising a proton-donating wetting agent, whereby the wetting agent forms a complex with the hydrophilic monomer on the surface of the medical device in the absence of a surface oxidation treatment step and without the addition of a coupling agent.
Claims17
A method for improving the wettability of a medical device, comprising the steps of:
- (a) providing a medical device formed from a monomer mixture comprising a hydrophilic monomer and a silicone-containing monomer, wherein said medical device has not been subjected to a surface oxidation treatment;
- (b) contacting a surface of the medical device with a wetting agent solution comprising at least one proton-donating wetting agent selected from the group consisting of P(vinylpyrolidinone(VP)-co-acrylic acid(AA)), P(methylvinylether-alt-maleic acid), P(acrylic acid-graft-ethyleneoxide), P(acrylic acid-co-methacrylic acid), P(acrylamide-co-AA), P(acrylamide-co-AA), P(AA-co-maleic), and P(butadiene-maleic acid), whereby the wetting agent forms a complex with the hydrophilic monomer on the surface of the medical device in the absence of a surface oxidation treatment step and without the addition of a coupling agent.
A method for improving the wettability of a medical device, comprising the steps of:
- (a) providing a medical device formed from a monomer mixture comprising a hydrophilic monomer and a silicone-containing monomer, wherein said medical device has not been subjected to a surface oxidation treatment;
- (b) contacting a surface of the medical device with a solution comprising a wetting agent selected from the group consisting of polymers or copolymers of (meth)acrylic acid, whereby the wetting agent forms a complex with the hydrophilic monomer on the surface of the medical device in the absence of a surface oxidation treatment step and without the addition of a coupling agent.
A method for improving the wettability of a medical device comprising the steps of:
- (a) providing a medical device formed from a monomer mixture comprising a silicone-containing monomer and at least one hydrophilic monomer selected from the group consisting of N-vinyl-2-pyrrolidone and N,N-dimethylacrylamide, wherein said medical device has not, been subjected to a surface oxidation treatment;
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- (b) contacting a surface of the medical device with a solution comprising at least one selected from the group consisting of poly(acrylic acid) and poly(acrylic acid-co-acrylamide).
Dependencies are inferred from the claim text.