Bioadhesive nanoparticulate compositions having cationic surface stabilizers

A stable bioadhesive nanoparticulate composition comprising:

• (a) active agent particles in a semi-crystalline state, an amorphous state, a mixture of crystalline and semi-crystalline, a mixture of crystalline and amorphous, or a mixture of crystalline, semi-crystalline, and amorphous, wherein the active agent particles are present in an amount of about 99.99 to 0.01(w/w) based on the total weight of the composition;
• and
• (b) adsorbed to the surface thereof at least one cationic surface stabilizer,
• wherein the active agent particles have an effective average particle size of less than about 4000 nm, and wherein the nanoparticulate composition adsorbs to a biological surface.

A stable bioadhesive nanoparticulate composition comprising:

• (a) active agent particles in a semi-crystalline state, an amorphous state, a mixture of crystalline and semi-crystalline, a mixture of crystalline and amorphous, or a mixture of crystalline, semi-crystalline, and amorphous;
• and
• (b) adsorbed to the surface thereof at least one cationic surface stabilizer, wherein the surface stabilizer is present in an amount of about 0.001 to about 99.999% (w/w) based on the total weight of the composition,
• wherein the active agent particles have an effective average particle size of less than about 4000 nm, and wherein the nanoparticulate composition adsorbs to a biological surface.