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US 6,428,579 B1Granted
Implantable prosthetic devices coated with bioactive molecules
AssigneeBrown University Research Foundation
InventorRobert F. Valentini
Life of this patent
Estimating the term…
Abstract
Coated implantable prosthetic devices are disclosed. The device is a prosthetic having a gold layer on the surface to which bioactive molecules are attached through a gold-sulfhydryl bond. The devices are easy and convenient to prepare. Gold coated implantable devices are also disclosed herein. The gold coated implantable device is a prosthetic device formed of a porous non-fabric material having a surface with projections and indentations and the gold layer on the surface of the porous non-fabric material forms a uniform layer across the material such that the gold layer also forms projections and indentations.
Claims39
A prosthetic device, comprising:
- a shaped substrate having a substrate surface, for implantation in a mammal;
- a layer of gold attached to the substrate surface and defining a tissue contacting surface;
- wherein the gold layer has a thickness of about 10 to 1000 Angstroms and,
- a bioactive peptide bound to the gold layer.
1 more element
A prosthetic device, comprising:
- a shaped substrate having a substrate surface, for implantation in a mammal;
- a layer of gold attached to the substrate surface and defining a tissue contacting surface;
- and, a bioactive peptide bound to the gold layer wherein the bioactive peptide is a chemotactic peptide and, wherein the chemotactic peptide is selected from the group consisting of functionally active fragments of collagen, fibronectin, laminin, and proteoglycan.
A prosthetic device, comprising:
- a shaped substrate having a substrate surface, for implantation in a mammal;
- a layer of gold attached to the substrate surface and defining a tissue contacting surface;
- and, a bioactive peptide bound to the gold layer, wherein the bioactive peptide is an anti-tumor peptide and, wherein the anti-tumor peptide is selected from the group consisting of functionally active fragments of protein anti-tumor molecules.
A prosthetic device, comprising:
- a shaped substrate having a substrate surface, for implantation in a mammal;
- a layer of gold attached to the substrate surface and defining a tissue contacting surface;
- and, a bioactive peptide bound to the gold layer, wherein the bioactive peptide is a growth potentiating peptide and, wherein the growth potentiating peptide is selected from the group consisting of functionally active fragments of PDGF, EGF, FGF, TGF, NGF, CNTF, GDNF, and type I collagen peptides.
A prosthetic device, comprising:
- a shaped substrate having a substrate surface, for implantation in a mammal;
- a layer of gold attached to the substrate surface and defining a tissue contacting surface;
- and, a bioactive peptide bound to the gold layer, wherein the bioactive peptide forms a layer about 1 to 500 Angstroms in thickness.
A prosthetic device, comprising:
- a shaped substrate having a substrate surface, for implantation in a mammal;
- a layer of gold attached to the substrate surface and defining a tissue contacting surface;
- and, a bioactive peptide bound to the gold layer, wherein the bioactive molecule is bound to the gold by a gold-sulfide bond.
A prosthetic device, comprising:
- a shaped substrate formed of a textured material having a substrate surface with first projections and first indentations;
- and
- a layer of gold attached to the substrate surface of the textured material, wherein the layer of gold creates a gold surface that has second projections said second indentations corresponding to said first projections and indentations.
A prosthetic device, comprising:
- a shaped substrate having a substrate surface;
- a layer of gold attached to the substrate surface;
- and
- an RGDC peptide attached to the gold layer through a gold-sulfide bond, wherein the RGDC peptide forms a layer about 1 to 500 Angstroms in thickness.
1 more element
A prosthetic device, comprising:
- a shaped substrate having a substrate surface;
- a layer of gold attached to the substrate surface;
- and
- an RGDC peptide attached to the gold layer through a gold-sulfide bond, wherein the gold layer has a thickness of about 10 to 1000 Angstroms.
1 more element
A prosthetic device, comprising:
- a shaped substrate having a substrate surface;
- a layer of gold attached to the substrate surface;
- and
- an RGDC peptide attached to the gold layer through a gold-sulfide bond, wherein the surface of the prosthetic device is formed of a porous material and wherein the layer of gold creates a gold surface that has projections and indentations and wherein the layer of gold has an approximately uniform thickness across the surface of the porous material.
1 more element
A prosthetic device, comprising:
- a shaped substrate having a substrate surface, for implantation in a mammal;
- a layer of gold attached to the substrate surface and defining a tissue contacting surface;
- and,
- a bioactive molecule bound to the gold layer, wherein the bioactive molecule is selected from the group consisting of a cell modulating molecule, a chemotactic molecule, anticoagulant molecule, antithrombotic molecule, an anti-tumor molecule, an anti-infectious molecule, a growth potentiating molecule, and an anti-inflammatory molecule.
1 more element
A prosthetic device, comprising:
- a shaped substrate having a substrate surface, for implantation in a mammal;
- a layer of gold attached to the substrate surface and defining a tissue contacting surface;
- and,
- a bioactive molecule bound to the gold layer, wherein the gold layer has a thickness of about 10 to 1000 Angstroms.
1 more element
A prosthetic device, comprising:
- a shaped substrate having a substrate surface, for implantation in a mammal;
- a layer of gold attached to the substrate surface and defining a tissue contacting surface;
- and,
- a bioactive molecule bound to the gold layer, wherein the bioactive molecule forms a layer about 1 to 500 Angstroms in thickness.
1 more element
A prosthetic device, comprising:
- a shaped substrate having a substrate surface, for implantation in a mammal;
- a layer of gold attached to the substrate surface and defining a tissue contacting surface;
- and,
- a bioactive molecule bound to the gold layer, wherein the surface of the prosthetic device is formed of a porous material and wherein the layer of gold creates a gold surface that has projections and indentations said corresponding to the projections and indentations.
1 more element
Dependencies are inferred from the claim text.