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US 6,426,208 B1Granted
Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof
AssigneeHarbor-UCLA Research and Education Institute
InventorsEmil D. Kakkis, Becky Tanamachi
Life of this patent
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Abstract
The present invention provides a recombinant α-L-iduronidase and biologically active fragments and mutants thereof, methods to produce and purify this enzyme as well as methods to treat certain genetic disorders including- α-L-iduronidase deficiency and mucopolysaccharidosis I (MPS 1).
Claims7
A purified human recombinant α-L-iduronidase having a purity of greater than about 99%, wherein said purified human recombinant α-L-iduronidase comprises the amino acid sequence of residues 26 to 653 of SEQ ID NO:2.
Dependencies are inferred from the claim text.