Method for the functional detection of disorders in the protein C system
AssigneePentapharm AG
InventorsKurt Stocker, Patrizia Gempeler-Messina, Christian Müller
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Abstract
The method relates to a method for detecting disorders in the protein C system, and in particular for determining the activated blood coagulation factor V with increased stability with respect to decomposition by activated protein C.
Claims26
A method for the qualitative detection and/or quantitative determination of disorders in the protein C system, comprising incubating a plasma sample with a protein C activator and/or APC, triggering off the coagulation by the addition of a calcium-independent prothrombin activator without addition of calcium ions to the test mixture, measuring the clotting time, comparing the latter with the clotting time with or without protein C activator and/or APC of a reference plasma sample and detecting the disturbance in the protein C system therefrom.
A test kit for the qualitative detection and/or quantitative determination of disorders of the protein C system, comprising APC or a protein C activator and a calcium-independent prothrombin activator but no calcium ions.
Dependencies are inferred from the claim text.