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US 6,425,918 B1Granted
Polysaccharide sponges for cell culture and transplantation
AssigneeBen-Gurion University of the Negev
InventorsLilia Shapiro, Rachel Glicklis, Smadar Cohen
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Abstract
A polysaccharide sponge characterized by having: (i) an average pore size in the range between about 10 μm to about 300 μm; (ii) an average distance between the pores being the wall thickness of the pores in the range between about 5 μm to about 270 μm; and (iii) an E-modulus of elasticity being a measure of the rigidity of the sponge in the range of about 50 kPa to about 500 kPa.
Claims17
A polysaccharide sponge characterized by having:
- (i) an average pore size in the range between about 10 μm to about 300 μm;
- (ii) an average distance between the pores being the wall thickness of the pores in the range between about 5 μm to about 270 μm;
- and (iii) an E-modulus of elasticity being a measure of the rigidity of the sponge in the range of about 50 kPa to about 500 kPa, wherein said sponge comprises an alginate selected from the group of alginates characterised by having:
- (i) a mannuronic acid (M) residue content in the range of between about 25% and about 65% of total residues;
- (ii) a guluronic acid (G) residue content in the range of between about 35% and about 75% of total residues;
- (iii) a M/G ratio of about ⅓ and about 1.86/1;
- and (iv) a viscosity of the final alginate solution having 1% w/v alginate, from which the sponge is obtained in the range between about 50 cP to about 800 cP.
4 more elements
Dependencies are inferred from the claim text.