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US 6,423,681 B1Granted
Method of inducing formation of kidney epithelia from mesenchymal precursors
AssigneeThe Trustees of Columbia University in the City of New York
InventorsJonathan M. Barasch, Juan A. Oliver, Jun Yang
Life of this patent
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Abstract
This invention provides methods of using a gpl3O receptor ligand, e.g. leukemia inhibitory factor, to induce the formation of kidney epithelia, to treat subjects suffering from kidney failure, and to preserve kidneys for transplantation.
Claims10
A method of treating a subject with diminished kidney function which comprises:
- (a) treating fetal tissue, fetal cells, or fetal or postnatal precursor or stem cells ex vivo with a gp130 receptor ligand in the presence of a growth factor, and
- (b) transplanting the so treated fetal tissue, fetal cells, or fetal or postnatal precursor or stem cells into the subject with diminished kidney function.
Dependencies are inferred from the claim text.