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US 6,423,344 B1Granted
Dispersible macromolecule compositions and methods for their preparation and use
AssigneeInhale Therapeutic Systems
InventorsRobert M. Platz, Thomas K. Brewer, Terence D. Boardman
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Abstract
A process for preparing ultrafine powders of biological macromolecules comprises atomizing liquid solutions of the macromolecules, drying the droplets formed in the atomization step, and collecting the particles which result from drying. By properly controlling each of the atomization, drying, and collection steps, ultrafine dry powder compositions having characteristics particularly suitable for pulmonary delivery for therapeutic and other purposes may be prepared.
Claims15
A method for preparing dispersible dry powders of biological macromolecules, said method consisting of:
- providing an evaporable liquid medium containing a predetermined concentration of the macromolecule and excipients;
- atomizing the liquid medium under predetermined atomizing conditions;
- drying the droplets in a heated gas stream under drying conditions selected to form dispersible particles of the composite material containing the biological macromolecules, said atomizing conditions in combination with said drying conditions being effective to produce particles comprising a rugosity of at least 2.0 as measured by air permeametry, a moisture content below 10% by weight and a particle size of less than 10 microns;
- and
- collecting said particles.
2 more elements
Dependencies are inferred from the claim text.